THEME08-9-1015-96/2008

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08-9-1015-96/2008

Priority:

Status:

In-progress

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Project scientific leaders:

E.A. Krasavin
V.E. Aleinikov

Participating Countries, Institutes and International organizations
Armenia, Belarus, Bulgaria, Hungary, Germany, Mongolia, JINR, USA, Slovakia, Ukraine, Russia, Czechia, CERN.

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental research at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- Theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- Experimental data obtained for verification of theoretical modeling of ionizing radiation interaction with matter;
- Investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- The problem of low doses of radiation with different LET and cell recovery;
- Genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- Investigation of "methylene blue - ²¹¹At" complex therapy efficiency in melanoma cells.

As the results:
- Methods for radiation and genetic monitoring at nuclear installations of JINR and in environment will be developed;
- Fundamental data for radiation risk assessments will be obtained;
- Methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2005:

Main characteristics of the radiation fields at the JINR basic facilities and in the environment.
Calculations of nuclear facilities radiation shields.
Data about the regularities of induction of stable chromosomal aberrations in human lymphocytes after irradiation by high-energy magnesium ions.
Data about the induction and reparation of duplex cuts of DNA in human cells after irradiation by carbon ions with 500 MeV/n energy.
Data about citogenetic effects of magnesium ions with 500 MeV/n energy at low doses.
Data about the kinetics of lens crystallins aggregation under the action of accelerated charged particles.
Actual data organization and manufacture of radiopharmaceutical based on ¹³¹I-MTB for a clinical trials.
Measurements of the dosimetric characteristics of the heavy nuclei beams for the radiobiological experiments.
MD simulation of the structural changes and conformational dynamics of the rodopsins.

List of Activities:

Activity or Experiment

Leader

Status

Radiation research

V.E. Aleinikov

Preparation
Data taking
R&D

Radiobiological research
at heavy charged
particle beams

E.A. Krasavin

Data taking
Realization
R&D

Radiobiological research
with radionuclids

E.A. Krasavin
N.L. Shmakova
V.N. Korsounski

Data taking
R&D

Training activity

V.E. Aleinikov
E.A. Krasavin
S.P. Ivanova

Collaboration
Country or international organization	City	Institute or Laboratory
Armenia	Yerevan	YerPhI
Belarus	Minsk	IRB NASB
Bulgaria	Sofia	INRNE BAS
CERN	Geneva
Czech Republic	Brno	IBP ASCR
	Rez	NPI ASCR
Germany	Cologne	DLR
Hungary	Debrecen	Atomki
JINR	Dubna	VBLHE
		DLNP
		FLNR
		LIT
		UC
Mongolia	Ulaanbaatar	NUM
Poland	Cracow	NINP
	Otwock-Swierk	IAE
Russia	Moscow	RCRC RAMS
		SRC-IBMP
	Gatchina	PNPI RAS
	Puschino	ITEB RAS
Slovak Republic	Bratislava	IPCM
Ukraine	Kiev	ICBGE NASU
	Sevastopol	IBSS NASU
The USA	Houston, TX	NASA

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Radiation and Radiobiological Investigations at the JINR Basic Facilities and in the Environment

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment